International Journal of Mathematical, Engineering and Management Sciences

ISSN: 2455-7749

Effect of Alcohol Consumption during Antiretroviral Therapy on HIV-1 Replication: Role of Cytochrome P3A4 Enzyme

Srijita Mondal
Centre for Mathematical Biology and Ecology, Department of Mathematics, Jadavpur University, Kolkata - 700032, India.

Priyanka Ghosh
Centre for Mathematical Biology and Ecology, Department of Mathematics, Jadavpur University, Kolkata - 700032, India.

Dibyendu Biswas
Department of Mathematics, City College of Commerce and Business Administration, 13, Surya Sen Street, Kolkata-700012, India.

Priti Kumar Roy
Centre for Mathematical Biology and Ecology, Department of Mathematics, Jadavpur University, Kolkata - 700032, India.

DOI https://dx.doi.org/10.33889/IJMEMS.2019.4.4-073

Received on July 18, 2018
  ;
Accepted on April 19, 2019

Abstract

Alcohol consumption is prevalent in HIV/AIDS infected patients. It possesses serious effects on protease inhibitors (PIs), which are used as an antiviral drug. While taking PIs, the secretion of Cytochrome P3A4 (CYP3A4) enzymes occurs from the liver and it metabolizes the drug to CYP3A4-PI complex. Alcohol consumption increases the rate of metabolism of PIs. In this research article, we have formulated a set of nonlinear differential equations based on the enzymatic activity of CYP3A4 for alcoholic HIV infected patients. Here, we have analytically compared the dynamics of PIs metabolism between alcoholic and non-alcoholic HIV infected patients and also investigated how the infection is being accelerated by enhancing viral load due to alcohol consumption. Finally, our analytical results are verified by numerical findings.

Keywords- HIV/AIDS, Viral load, Alcohol consumption, CYP3A4 enzyme, Protease inhibitor.

Citation

Mondal, S., Ghosh, P., Biswas, D., & Roy, P. K. (2019). Effect of Alcohol Consumption during Antiretroviral Therapy on HIV-1 Replication: Role of Cytochrome P3A4 Enzyme. International Journal of Mathematical, Engineering and Management Sciences, 4(4), 922-935. https://dx.doi.org/10.33889/IJMEMS.2019.4.4-073.

Conflict of Interest

The authors confirm that there are no known conflicts of interest associated with this publication.

Acknowledgements

Srijita Mondal and Priyanka Ghosh are the recipient of “Innovation in Science Pursuit for Inspired Research” (INSPIRE) Program Fellowship, Department of Science and Technology, Government of India.

References

Acosta, E.P. (2002). Pharmacokinetic enhancement of protease inhibitors. Journal of Acquired Immune Deficiency Syndromes (1999), 29, S11-8.

Biswas, D., Datta, A., & Roy, P.K. (2016). Combating Leishmaniasis through awareness campaigning: a mathematical study on media efficiency. International Journal of Mathematical, Engineering and Management Sciences, 1(3), 139-149.

Chander, G. (2011). Addressing alcohol use in HIV-infected persons. Topics in Antiviral Medicine, 19(4), 143-147.

Chander, G., Himelhoch, S., Fleishman, J.A., Hellinger, J., Gaist, P., Moore, R.D., & Gebo, K.A. (2009). HAART receipt and viral suppression among HIV-infected patients with co-occurring mental illness and illicit drug use. AIDS Care, 21(5), 655-663.

Chander, G., Lau, B., & Moore, R.D. (2006). Hazardous alcohol use: a risk factor for non-adherence and lack of suppression in HIV infection. Journal of Acquired Immune Deficiency Syndromes (1999), 43(4), 411-417.

Chatterjee, A.N., & Roy, P.K. (2012). Anti-viral drug treatment along with immune activator IL-2: a control-based mathematical approach for HIV infection. International Journal of Control, 85(2), 220-237.

Chowdhury, S., & Roy, P.K. (2016). Mathematical modelling of enfuvirtide and protease inhibitors as combination therapy for HIV. International Journal of Nonlinear Sciences and Numerical Simulation, 17(6), 259-275.

Das, K., & Arnold, E. (2013). HIV-1 reverse transcriptase and antiviral drug resistance. Part 1. Current Opinion in Virology, 3(2), 111-118.

Ferrari, L.F., & Levine, J.D. (2010). Alcohol consumption enhances antiretroviral painful peripheral neuropathy by mitochondrial mechanisms. European Journal of Neuroscience, 32(5), 811-818.

Flexner, C.W., Cargill, V.A., Sinclair, J., Kresina, T.F., & Cheever, L. (2001). Alcohol use can result in enhanced drug metabolism in HIV pharmacotherapy. AIDS Patient Care and STDs, 15(2), 57-58.

Ghosh, P., & Roy, P.K. (2018). Mathematical modelling of methanol poisoning with impulsive dosing of antidote therapeutics to prevent toxicity. Mathematical Methods in the Applied Sciences, 41(18), 9176-9190.

Ghosh, P., Cao, X., Pal, J., Chowdhury, S., Saha, S., Nandi, S., & Roy, P.K. (2018). Mathematical modeling for the prevention of methanol poisoning through ethanol by impulsive way. Differential Equations and Dynamical Systems, 1-18.

Gonzalez, A., Barinas, J., & O’Cleirigh, C. (2011). Substance use: impact on adherence and HIV medical treatment. Current HIV/AIDS Reports, 8(4), 223-234.

Goudar, C.T., Sonnad, J.R., & Duggleby, R.G. (1999). Parameter estimation using a direct solution of the integrated Michaelis-Menten equation. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology, 1429(2), 377-383.

Hendershot, C.S., Stoner, S.A., Pantalone, D.W., & Simoni, J.M. (2009). Alcohol use and antiretroviral adherence: review and meta-analysis. Journal of Acquired Immune Deficiency Syndromes (1999), 52(2), 180-202.

Hirsch, M.S., Günthard, H.F., Schapiro, J.M., Vézinet, F.B., Clotet, B., Hammer, S.M., Johnson, V.A., Kuritzkes, D.R., Mellors, J.W., Pillay, D., Yeni, P.G, Jacobsen, D.M., & Richman, D.D. (2008). Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Clinical Infectious Diseases, 47(2), 266-285.

Kostyuchenko, Y.V. (2018). On the methodology of satellite data utilization in multi-modeling approach for socio-ecological risks assessment tasks: a problem formulation. International Journal of Mathematical, Engineering and Management Sciences, 3(1), 1-8.

Kumar, S., & Kumar, A. (2011). Differential effects of ethanol on spectral binding and inhibition of cytochrome P450 3A4 with eight protease inhibitors antiretroviral drugs. Alcoholism: Clinical and Experimental Research, 35(12), 2121-2127.

Kumar, S., Jin, M., Ande, A., Sinha, N., Silverstein, P.S., & Kumar, A. (2012). Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes. Expert Opinion on Drug Metabolism & Toxicology, 8(11), 1363-1375.

Lou, J., & Smith, R.J. (2011). Modelling the effects of adherence to the HIV fusion inhibitor enfuvirtide. Journal of Theoretical Biology, 268(1), 1-13.

Midde, N.M., Rahman, M.A., Rathi, C., Li, J., Meibohm, B., Li, W., & Kumar, S. (2016). Effect of ethanol on the metabolic characteristics of HIV-1 integrase inhibitor elvitegravir and elvitegravir/cobicistat with CYP3A: An analysis using a newly developed LC-MS/MS method. PloS one, 11(2), e0149225.

Miguez, M.J., Shorposner, G.A.I.L., Morales, G., Rodriguez, A., & Burbano, X. (2003). HIV treatment in drug abusers: impact of alcohol use. Addiction Biology, 8(1), 33-37.

Norman, L.R., & Kumar, A. (2006). Neuropscyhological complications of HIV disease and substances of abuse. American Journal of Infectious Diseases, 2(2), 67-73.

Pal, D., & Mitra, A.K. (2006). MDR-and CYP3A4-mediated drug–drug interactions. Journal of Neuroimmune Pharmacology, 1(3), 323-339.

Purohit, V., Rapaka, R., & Shurtleff, D. (2011). Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia. Molecular Neurobiology, 44(1), 102-110.

Roy, P.K., Saha, S., & Al Basir, F. (2015). Effect of awareness programs in controlling the disease HIV/AIDS: an optimal control theoretic approach. Advances in Difference Equations, 2015(1), 217-234.

Schulz, A.R. (1994). Enzyme kinetics: from diastase to multi-enzyme systems. Cambridge University Press.

Segel, L.A. (1984). Modeling dynamic phenomena in molecular and cellular biology. Cambridge University Press.

Smith, R.J. (2008). Explicitly accounting for antiretroviral drug uptake in theoretical HIV models predicts long-term failure of protease-only therapy. Journal of Theoretical Biology, 251(2), 227-237.

Smith, R.J., & Wahl, L.M. (2004). Distinct effects of protease and reverse transcriptase inhibition in an immunological model of HIV-1 infection with impulsive drug effects. Bulletin of Mathematical Biology, 66(5), 1259-1283.

Smith, R.J., & Wahl, L.M. (2005). Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects. Bulletin of Mathematical Biology, 67(4), 783-813.

Song, B.J., Lou, J., & Wen, Q.Z. (2011). Modelling two different therapy strategies for drug T-20 on HIV-1 patients. Applied Mathematics and Mechanics, 32(4), 419-436.

Walubo, A. (2007). The role of cytochrome P450 in antiretroviral drug interactions. Expert Opinion on Drug Metabolism & Toxicology, 3(4), 583-598.

Witteveen, E., & van Ameijden, E.J. (2002). Drug users and HIV-combination therapy (HAART): factors which impede or facilitate adherence. Substance Use & Misuse, 37(14), 1905-1925.

Xu, L., & Desai, M.C. (2009). Pharmacokinetic enhancers for HIV drugs. Current opinion in investigational drugs (London, England: 2000), 10(8), 775-786.

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